Antibiotic prophylaxis for hysterectomy and cesarean section: Amoxicillin-clavulanic acid versus cefazolin

Shetty, Jyothi and Vyas, Neetha M and Kumar, Pratap and Kamath, Asha (2010) Antibiotic prophylaxis for hysterectomy and cesarean section: Amoxicillin-clavulanic acid versus cefazolin. The Journal of Obstetrics and Gynecology of India, 60 (5). pp. 419-423. ISSN 0971-9202

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Abstract

Objective: To compare amoxycillin-clavulanic acid with cefazolin as short term antibiotic prophylaxis in women undergoing hysterectomy and elective cesarean section. Method: Sixty women undergoing hysterectomy were randomly assigned either to 2.4g intravenous amoxycillin-clavulanic acid (AMX/CL) or 2g cefazolin 30 min before hysterectomy. One hundred and twenty two women delivered by elective cesarean were randomized to a single dose of either of the above antibiotics at cord clamping. Each patient was assessed daily until discharge for evidence of febrile status and the presence of infection at the operative site and urinary tract. Results: Infectious morbidity was found in 11% and 12.5% of hysterectomy patients inAMX/CL and cefazolin groups respectively. Ten women had post-cesarean infections (sixAMXCL, four cefazolin, P=0.51) Conclusion: Broad spectrum amoxycillin-clavulanic acid was not superior to cefazolin in the prevention of postoperative infection when given as prophylaxis in hysterectomy and elective cesarean cases.

Item Type: Article
Uncontrolled Keywords: Antibiotic prophylaxis; hysterectomy; abdominal; vaginal; cesarean delivery; elective; emergency.
Subjects: Medicine > KMC Manipal > Community Medicine
Medicine > KMC Manipal > Obstetrics & Gynaecology
Depositing User: KMC Library
Date Deposited: 26 Sep 2015 11:33
Last Modified: 26 Sep 2015 11:33
URI: http://eprints.manipal.edu/id/eprint/144160

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