Medical abortion by mifepristone with sublingual vs vaginal misoprostol: A randomised comparative trial

Shetty, Jyothi and Shanmugapriya, T and Kamath, Asha (2008) Medical abortion by mifepristone with sublingual vs vaginal misoprostol: A randomised comparative trial. Health and Population: Perspectives and Issues, 31 (4). pp. 221-228.

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Abstract

To compare the success and side-effects between the sublingual and the vaginal administration of Misoprostol for induced abortion in women treated initially with Mifepristone. We administered 200 mg of Mifepristone to 117 women who requested termination of pregnancy of under-9 weeks. Forty-eight hours later they were randomised into two groups. Fifty-eight women received two doses of Misoprostol sublingually 3 hrs apart, while 59 women received Misoprostol 800 mcg vaginally. They were observed for 3 hrs and returned on 15 day for final assessment. Complete abortion occurred in 96.5% (95% CI: 91-100) of the women in the sublingual group and 96.6% (95% CI: 91-100) in the vaginal group. This regimen resulted in complete abortion in all women (100%) when it was administered before 7 weeks gestation. The median induction-to-abortion interval was shorter in women in the sublingual group compared to the vaginal group (P <0.001). Women in the sublingual group experienced more diarrhoea (P = 0.005), chills (P <0.001) and fever (P = 0.001). Two doses of sublingual Misoprostol administered after Mifepristone is an effective alternative route to the standard vaginal administration for medical abortion.

Item Type: Article
Uncontrolled Keywords: Mifepristone; misoprostol; s ublingual; vaginal.
Subjects: Medicine > KMC Manipal > Community Medicine
Medicine > KMC Manipal > Obstetrics & Gynaecology
Depositing User: KMC Library
Date Deposited: 28 Sep 2015 09:02
Last Modified: 28 Sep 2015 09:02
URI: http://eprints.manipal.edu/id/eprint/144164

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