Fine Needle Aspiration of Goiter (Benign and Non-Neoplastic) with Thyroid Function Abnormalities

Saha, Debarshi and *, Akshay Krishnamurthy and *, Ashwani Kumar and Sinha, Ruchi and Kini, Jyoti R. (2015) Fine Needle Aspiration of Goiter (Benign and Non-Neoplastic) with Thyroid Function Abnormalities. Journal of International Dental and Medical Research, 1 (6). pp. 26-31.

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Introduction: A thyroid nodule is the prime indication for FNA, which is also a cheap and effective investigation. The current study seeks an association between benign goiter and aberrant thyroid function tests. Can thyroid FNA anticipate overt morbidity resulting from thyroid function abnormalities? Materials and methods: FNA records of 173 patients were studied along with thyroid function test(TFT) results. Slide review was undertaken where FNA impression did not correspond to the TFT. Results:The female: male ratio was 149:24. Two(1.15%) had inadequate cellularity. 95/173 cases had abnormal TFTs. Multinodulargoiter(126), Hashimoto thyroiditis(43) and two and one case of granulomatous and unclassified thyroiditis respectively constituted our diagnostic profile. Abnormalities in TFT did not correlate with age group, gender or FNA diagnoses. However, hypothyroidism (clinical and subclinical) was significantly observed in Hashimoto thyroiditis(HT) cases. Again, scant colloid and cell change significantly correlated with HT. The histological correlation was obtained in 46 cases. Four neoplastic cases were seen, among which there were three papillary carcinomas focally arising within cysts. Conclusions: The major observation in this study is the subset of euthyroid and subclinically hypothyroid cases (23/43, 53.48%) of Hashimoto thyroiditis (p = 0.0021). If treated with thyroxine replacement, overt hypothyroidism, particularly in pregnant women who are at risk of developing antithyroid antibodies, may be prevented. In addition, inadequacy rate (1.15%) in the current study is low. False negatives 3/46(6.5%), though available on a meager and selected subset of the patient population is still within the range of published data.

Item Type: Article
Uncontrolled Keywords: Fine-needle aspiration, goiter, Hashimoto thyroiditis, Multinodular goiter, Hyperthyroidism
Subjects: Medicine > KMC Mangalore > Pathology
Depositing User: KMCMLR User
Date Deposited: 28 Sep 2015 12:03
Last Modified: 28 Sep 2015 12:03

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