What does fetal autopsy unmask in oligohydramnios?

Nayak, Shalini S and Shukla, Anju and Kodandapani, Sreelakshmi and Adiga, Prashanth K and Girisha, KM (2015) What does fetal autopsy unmask in oligohydramnios? The Journal of Maternal-Fetal & Neonatal Medicine. pp. 1-5. ISSN 1476-7058

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Objective: We aimed to determine the value of autopsy in fetuses with antenatally diagnosed oligohydramnios. Patients and methods: We evaluated all fetal losses over a period of 6.5 years. Those with oligohydramnios on antenatal scan were critically analyzed. Oligohydramnios was defined as amniotic fluid index of less than five objectively or as an obvious lack of liquor at subjective assessment. A detailed postmortem examination was carried out in all the fetuses after obtaining an informed consent. Results: Fetal autopsy was conducted in 255 cases. Fifty-five (21.5%) fetuses were diagnosed to have oligohydramnios on antenatal ultrasonography. On analysis of antenatal causes of oligohydramnios, maternal/placental factors were noted in 18%, ultrasound findings known to affect amniotic fluid in 27% while cause remained unidentified in 54.5% of cases. On autopsy, fetal malformations were noted in 61.8% cases, intrauterine growth retardation in 21.8% fetuses and no obvious malformations in 16.3% fetuses. Renal anomalies were noted in 40% cases and non-renal malformations in 21.8% cases. Conclusion: The postmortem examination helped us to identify the cause of fetal loss in 46 (83.6%) fetuses with antenatal oligohydramnios. A working diagnosis could not have been established without autopsy in 19 (34.5%) cases.

Item Type: Article
Uncontrolled Keywords: Amniotic fluid; anhydramnios; fetal anomalies; genetic counseling; malformation; ultrasonography.
Subjects: Medicine > KMC Manipal > Medical Genetics
Medicine > KMC Manipal > Obstetrics & Gynaecology
Depositing User: KMC Library
Date Deposited: 29 Sep 2015 14:57
Last Modified: 18 May 2022 16:16
URI: http://eprints.manipal.edu/id/eprint/144221

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