A Novel Gene THSD7A is Associated with Obesity

Rotti, H and Raval, R and Nair, S and Gopinath, PM and Satyamoorthy, K (2015) A Novel Gene THSD7A is Associated with Obesity. International Journal of Obesity. pp. 1-4.

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Body mass index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian populations are admixture of two ancestral populations; ancestral north Indians (ANI) and ancestral south Indians (ASI). Although ANI are related to Europeans, ASI are not related to any group outside Indian-subcontinent. Hence, we expect novel genetic loci associated with BMI. In association analysis, we found eight genic SNPs in extreme of distribution (Pless than or equal to3.75 × 10−5), of which WWOX has already been reported to be associated with obesity-related traits hence excluded from further study. Interestingly, we observed rs1526538, an intronic SNP of THSD7A; a novel gene significantly associated with obesity (P=2.88 × 10−5, 8.922 × 10−6 and 2.504 × 10−9 in discovery, replication and combined stages, respectively). THSD7A is neural N-glycoprotein, which promotes angiogenesis and it is well known that angiogenesis modulates obesity, adipose metabolism and insulin sensitivity, hence our result find a correlation. This information can be used for drug target, early diagnosis of obesity and treatment.

Item Type: Article
Subjects: Departments at MU > Statistics
Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 01 Oct 2015 09:31
Last Modified: 01 Oct 2015 09:31
URI: http://eprints.manipal.edu/id/eprint/144240

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