HOMA IR/C Peptide Ratio – A Better Tool for Predicting Prognosis of Type II Diabetes Mellitus

Choudhry, AAfreen and Guddaiah, Rajeshwari and Prabhu, Krishnananda (2015) HOMA IR/C Peptide Ratio – A Better Tool for Predicting Prognosis of Type II Diabetes Mellitus. Journal of Pharmaceutical and Biomedical Sciences, 5 (8). pp. 650-654. ISSN 2230 – 7885

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Abstract

Background: Insulin resistance is a characteristic feature of type II diabetes which can precede and predict the disease. Homeostatic model assessment (HOMA) is a method for assessing insulin resistance (IR) from basal (fasting) glucose and insulin or Cpeptide concentrations. Insulin / c peptide ratio can act as a measure of insulin reserve which in addition indirectly can indicate insulin resistance. Also HOMA-IR / c peptide ratio indicates insulin resistance with respect to endogenous insulin reserve. The aim of this study was to compare the correlations of indices HOMA-IR, Insulin / c peptide ratio and HOMA-IR / c peptide ratio with glycated hemoglobin (HbA1c) and plasma lipid profile in type II diabetic patients. Methods: Blood glucose, HDL, total cholesterol, triglycerides and LDL were estimated in Cobas 6000 autoanalyser. Glycated hemoglobin was estimated by using HPLC in Variant turbo II. Insulin and C- peptide were estimated by chemiluminescence. Homeostatic model assessment (HOMA-IR) was calculated from basal (fasting) glucose and fasting insulin concentrations. Results: Strong and significant correlations were observed when HOMA IR/c peptide ratio was compared with HbA1c and plasma lipid profile parameters.Conclusion: This study indicated that among the indices Insulin / c peptide ratio and HOMA-IR / c peptide ratio and HOMA – IR, HOMA – IR/ c peptide correlated better with HbA1c and plasma lipid profile parameters and hence can be potential tool in evaluation, risk stratification and monitoring treatment of diabetes mellitus.

Item Type: Article
Uncontrolled Keywords: Diabetes mellitus; Insulin Resistance; HOMA model; C peptide
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Library
Date Deposited: 03 Oct 2015 09:08
Last Modified: 03 Oct 2015 09:08
URI: http://eprints.manipal.edu/id/eprint/144277

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