Curcumin half analog modulates interleukin‑6 and tumor necrosis factor‑alpha in inflammatory bowel disease

Kondamudi, Phani Krishna and Kovelamudi, Hemalatha and Nayak, Pawan G and Rao, Mallikarjuna C and Shenoy, Rekha R (2015) Curcumin half analog modulates interleukin‑6 and tumor necrosis factor‑alpha in inflammatory bowel disease. Pharmacognosy Magazine, 11 (44). S296-S302. ISSN 0973-1296

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Abstract

Background: The present study was aimed at examining the effect of dehydrozingerone (DHZ), half analogue of curcumin which is the active constituent of turmeric (Curcuma longa) in the di‑nitrochlorobenzene (DNCB) induced model for inflammatory bowel disease (IBD). Materials and Methods: Male Wistar rats (200–220 g) were divided into four groups (n = 6). Chemical induction of IBD was done by sensitizing with 300 μL of 20 g/L of DNCB (in acetone) onto the nape of rats for 14 days followed by intra‑colonic instillation of 250 μL of DNCB (0.1% DNCB in 50% alcohol) solution on day 15. Rats in Group 1 (normal control) and Group 2 (DNCB control) were treated with vehicle. Rats in Group 3 were treated with DHZ (100 mg/kg, p.o.; 8 days) and Group 4 animals were treated with sulfasalazine (SS) (100 mg/kg, p.o.; 8 days). On 24th day, the rats were killed, colon removed and the macroscopic, biochemical, and histopathological evaluations were performed. Results: The levels of myeloperoxidase, thiobarbituric acid reactive substrate, and nitrite increased significantly (P < 0.05) in the DNCB group whereas reduced significantly in the DHZ and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. Interleukin‑6, tumor necrosis factor‑alpha level was significantly high in the DNCB group. Conclusion: These findings show that DHZ can be a promising molecule for the treatment of IBD.

Item Type: Article
Uncontrolled Keywords: Dehydrozingerone; di‑nitro chlorobenzene; interleukin‑6; myeloperoxidase; thiobarbituric acid reactive substrate; tumor necrosis factor‑alpha.
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 03 Oct 2015 09:15
Last Modified: 03 Oct 2015 09:15
URI: http://eprints.manipal.edu/id/eprint/144283

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