Ginjupalli, Kishore (2014) Comparative antifungal efficacy of denture soft liners with clotrimazole: An invitro study. Indian Journal Of Dental Advancements, 6 (3). pp. 1593-1595.

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Abstract

Background: Candidal colonization on denture fitting surfaces is the major causative factor in denture stomatitis. Though various treatment options are available, a method by combining antifungal agents into soft liners seems to be a promising approach. Aim: To determine and compare antifungal activity of two soft liners combined with Clotrimazole against candida albicans. Materials and method: Two soft liners Coe soft (Acrylic) and GC Reline soft (Silicone) combined with Clotrimazole pure powder form and microsphere form at different concentrations (0.5, 1 and 1.5% w/v) were tested against candida albicans by agar disc diffusion method. After 24 hours of incubation, inhibition diameters were noted. One way analysis of variance followed by Tukey's post hoc test was used to test the inter group difference. P value < 0.05 was considered statistically significant. Results: Maximum inhibition was seen in the GC Reline soft with pure Clotrimazole followed by GC microsphere form followed by coe soft pure and microsphere forms at 1.5 and 1% W/V concentrations. There was no statistical significant inhibition between 1.5 and 1% W/V. Conclusion: Denture soft liners, when mixed with antifungal agents showed satisfactory inhibition of candida albicans suggesting that incorporation of antifungal agents into soft liners can be recommended for clinical use.

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