Comparative antifungal efficacy of denture soft liners with clotrimazole: An invitro study

Ginjupalli, Kishore (2014) Comparative antifungal efficacy of denture soft liners with clotrimazole: An invitro study. Indian Journal Of Dental Advancements, 6 (3). pp. 1593-1595.

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Background: Candidal colonization on denture fitting surfaces is the major causative factor in denture stomatitis. Though various treatment options are available, a method by combining antifungal agents into soft liners seems to be a promising approach. Aim: To determine and compare antifungal activity of two soft liners combined with Clotrimazole against candida albicans. Materials and method: Two soft liners Coe soft (Acrylic) and GC Reline soft (Silicone) combined with Clotrimazole pure powder form and microsphere form at different concentrations (0.5, 1 and 1.5% w/v) were tested against candida albicans by agar disc diffusion method. After 24 hours of incubation, inhibition diameters were noted. One way analysis of variance followed by Tukey's post hoc test was used to test the inter group difference. P value < 0.05 was considered statistically significant. Results: Maximum inhibition was seen in the GC Reline soft with pure Clotrimazole followed by GC microsphere form followed by coe soft pure and microsphere forms at 1.5 and 1% W/V concentrations. There was no statistical significant inhibition between 1.5 and 1% W/V. Conclusion: Denture soft liners, when mixed with antifungal agents showed satisfactory inhibition of candida albicans suggesting that incorporation of antifungal agents into soft liners can be recommended for clinical use.

Item Type: Article
Uncontrolled Keywords: Soft liners; Clotrimazole; microsphere; denture stomatitis.
Subjects: Dentistry > MCODS Manipal > Dental Materials
Depositing User: KMC Library
Date Deposited: 03 Oct 2015 09:43
Last Modified: 03 Oct 2015 09:43

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