Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents

Bolli, Keerthi Priya and Pai, Sreedhara Ranganath K (2015) Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents. European Journal of Medicinal Chemistry, 104. pp. 25-32. ISSN 0223-5234

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Abstract

Breast cancer is probably the most prevalent cancer in women. The development of resistance to therapeutic agents and lack of targeted therapy for breast cancer cells provide motivation to identify new compounds for the treatment. With this objective in mind, a new series of 3-fluoro-4-methoxyphenyl group based 1,3,5-trisubstituted aryl-5-hydroxypyrazoline analogues 4ael was synthesized through multi-step reaction sequence. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, LC-MS and elemental analysis. They were screened for their in vitro anticancer and in vitro antioxidant activities. Among the tested compounds 4h, 4c and particularly 4i displayed promising cytotoxic effect on breast cancer cell lines. The compounds were also found to possess antioxidant activity when tested against DPPH free radical. Overall, this work has contributed to the development of promising leads for anticancer and antioxidant activities.

Item Type: Article
Uncontrolled Keywords: Synthesis; hydroxypyrazolines; characterization; anticancer activity; antioxidant activity.
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 06 Oct 2015 09:15
Last Modified: 06 Oct 2015 09:15
URI: http://eprints.manipal.edu/id/eprint/144312

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