Study of uropathogens and its antibiogram at a tertiary care hospital at coastal Karnataka

Shobha, KL and D’Souza, Jessica Sushma and Alva, Meena and Anand, KM and Rao, Gowrish S and Ramachandra, L (2015) Study of uropathogens and its antibiogram at a tertiary care hospital at coastal Karnataka. International Journal of Pharmacy and Pharmaceutical Research, 4 (2). pp. 100-109. ISSN 2349-7203

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Introduction: Urinary tract infection (UTI) continues to be the commonest infection. Untreated cases can go in for complications. Empiric antimicrobial therapy reduces the complications thereby minimizing the cost of treatment. Since resistance rates differ from place to place, knowledge on prevailing patterns of antimicrobial resistance becomes essential. This study was carried out to investigate the etiologic agents of UTI in a tertiary care hospital and its antimicrobial susceptibility pattern. Materials and methods: Midstream urine samples collected from inpatients as well as outpatients in the hospital were inoculated onto the culture media. Strains having significant growth of 105 cfu/ml were processed for identification and antimicrobial susceptibility testing as per the CLSI guidelines. Results: The culture plate showed significant growth from 1368 urine samples (53% female and 47% male patients); of which 75% (1026) were from hospitalized patients. UTI was predominant in adults (86.54%) than in pediatrics (13.44%). E. coli (59.94%) was found to be the most common uropathogen followed by Klebsiella (16.37%). E. coli sensitive to Ampicillin and gentamicin was 43.75%. ESBL E. coli were 47.43%, MDR strains were 8.82%. Most of Enterococcus species and Staphylococcus species were sensitive to Ampicillin. Conclusion: Ampicillin or Gentamicin can be used for empirical treatment of UTI, but ESBL producers and MDR strains should also be considered. Knowledge on the antibiotic susceptibility testing pattern of the uropathogens is vital for proper treatment of UTI.

Item Type: Article
Uncontrolled Keywords: Urinary tract infection; E coli; ESBL’s; MDR strains.
Subjects: Medicine > MMMC Manipal > Microbiology
Medicine > KMC Manipal > Microbiology
Medicine > KMC Manipal > Surgery
Depositing User: KMC Library
Date Deposited: 08 Oct 2015 09:23
Last Modified: 08 Oct 2015 09:23

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