Statins:Beyond Cholesterol Lowering

Kumar, Sushil and Patil, Navin and Avinash, A and Pathak, Anurag and Avin, S and Adiga, Shalini (2015) Statins:Beyond Cholesterol Lowering. European Journal of Biomedical and Pharmaceutical Sciences, 2 (5). pp. 1572-1582. ISSN 2349-8870

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Abstract

Statins are most commonly prescribed drugs worldwide as cholestrol lowering agents. Several Observational studies have shown multi-faceted action in different pathological conditions by acting through cholesterol dependent as well as cholesterol independent mechanisms which affect several tssue functions.The end result is modulation of specific signal transduction pathways suggesting the ability of statins to exert pleiotropy.Pleiotropic effects or cholestrol independent effects inclue anti-inflammatory effects immunomodulation plaque stablizing effects anti-thrombotic antiplatelet effects and role in vascular dysfunction majority of these roles are due to inhibition of a process called isoprenylation thereby preventing activation of small GTPases which are pro inflammatory signaling molecules. Here is a review of pleiotropic effects of statin therapy and their role in non-cardiac diseases.

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