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A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult

*, Sridevi H.B. and *, Pooja K Suresh (2015) A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult. Journal of Cancer Research and Therapeutics, 11 (3). ISSN 0973-1482

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Abstract

Cutaneous anaplastic large cell lymphoma can present either as a primary disease or as secondary to a pre‑existing systemic anaplastic lymphoma. Distinguishing primary cutaneous anaplastic lymphoma (PC‑ALCL) from its systemic counterpart requires a complete clinical and laboratory workup. We hereby report a case of PC‑ALCL in a young adult, who presented with unusual rapidly progressive ulcerated mass in the neck. Biopsy showed anaplastic large cells, which were strongly positive for CD30 and CD25 but ALK1 gene product was negative. Clinical examination and computed tomography (CT) scan ruled out extracutaneous involvement. Chemotherapy with 6 cycles of CHOP regimen was planned and on follow‑up, a complete remission of the lesion was attained.

Item Type: Article
Uncontrolled Keywords: Anaplastic lymphoma kinase, aggressive, CD30, chemotherapy, primary cutaneous anaplastic large cell lymphoma
Subjects: Medicine > KMC Mangalore > Pathology
Depositing User: KMCMLR User
Date Deposited: 12 Oct 2015 15:15
Last Modified: 12 Oct 2015 15:15
URI: http://eprints.manipal.edu/id/eprint/144396

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