Conditioned Medium Reconditions Hippocampal Neurons against Kainic Acid Induced Excitotoxicity: An In Vitro Study

Bevinahal, Pradeep Kumar K and Venugopal, Chaitra and Prasad, Harish Chandra and Chandanala, Shashank and Bhonde, Ramesh R and Dhanushkodi, Anandh (2014) Conditioned Medium Reconditions Hippocampal Neurons against Kainic Acid Induced Excitotoxicity: An In Vitro Study. Journal of Toxicology, 2014. pp. 1-8.

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Abstract

Stem cell therapy is gaining attention as a promising treatment option for neurodegenerative diseases. The functional efficacy of grafted cells is a matter of debate and the recent consensus is that the cellular and functional recoveries might be due to “by-stander” effects of grafted cells. In the present study, we investigated the neuroprotective effect of conditioned medium (CM) derived from human embryonic kidney (HEK) cells in a kainic acid (KA) induced hippocampal degenerationmodel system in in vitro condition. Hippocampal cell linewas exposed toKA (200

Item Type: Article
Subjects: Regenerative Medicine > MIRM Bangalore
Depositing User: MCON Library
Date Deposited: 19 Nov 2015 16:29
Last Modified: 19 Nov 2015 16:29
URI: http://eprints.manipal.edu/id/eprint/144564

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