Comparative effect of betadine ointment and sodium fusidate cream on experimentally induced burnwound in wistar rats

Satyam, Shakta Mani and Bairy, KL (2015) Comparative effect of betadine ointment and sodium fusidate cream on experimentally induced burnwound in wistar rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6 (6). pp. 887-890. ISSN 0975-8585

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Abstract

Antibacterial agents like sodium fusidate, framycetin, calcium mupirocin are used topically to treat burn wounds. But their effect on healing as such is not known. The main objective of the present study is to compare the effect of sodium fusidate cream and betadine ointment on experimentally created burn wound healing in Wistar rats. The rats were anesthetized with ketamine 50mg/kg/ip before wounding. Burn wounds were created by pouring hot molten wax into a metal cylinder of 300 mm2 circular opening placed on shaven back of the rat. Animals were divided in to three groups of six rats each. Group I did not receive any drug and served as control group. Group II and III received 25-30 mg of betadine ointment and 25-30 mg of sodiumffusidate cream respectively once daily for 21 days or till complete epithelization whichever was earlier. Wound contraction and period of epithelization was noted in all the three groups by observing the animals daily. A significanltdercese in epithetlization and increase in % of wound contraction was observed with sodium fusidate cream compared to control and betadine group.

Item Type: Article
Uncontrolled Keywords: Epithelization; wound contraction; wound healing.
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 17 Nov 2015 12:01
Last Modified: 17 Nov 2015 12:01
URI: http://eprints.manipal.edu/id/eprint/144571

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