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Pancytopenia in Multiple Myeloma- An Enigma: Our Experience from Tertiary Care Hospital

*, Sridevi H.B. and Rai, Sharada and *, Pooja K Suresh and Minal, Jessica (2015) Pancytopenia in Multiple Myeloma- An Enigma: Our Experience from Tertiary Care Hospital. Journal of Clinical and Diagnostic Research, 9 (11). EC04-EC06. ISSN 0973-709X

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Abstract

Introduction: Multiple myeloma is a plasma cell neoplasm that is characterized by clonal proliferation of malignant plasma cell in the bone marrow along with M-protein in the serum and/or urine. Pancytopenia as a initial presentation of multiple myeloma is quite unusual. We are presenting a case series having pancytopenia as the presenting complaint. Materials and Methods: A retrospective study was conducted for a period of 30 months, wherein all the cases of multiple myeloma presenting with pancytopenia were included. The complete blood picture, peripheral smear examination, bone marrow aspirate & protein electrophoresis of all the cases were reviewed & analysed. Results: During the study period, 10 cases presented with pancytopenia with a mean age of 66.3 years (range: 59-72 years) at presentation with male: female ratio being 8:2. Fatigue and weakness was the most common symptom (100%) & average ESR was 104 mm/hour. High-resolution serum electrophoresis, showed a dense, sharp to wide M band in the gamma globulin region. Bone marrow plasma cell percentage was increased with an average of 63.1%. Bone marrow biopsy correlation was obtained in 100% cases. Conclusion: Diagnosing multiple myeloma, presenting as pancytopenia requires a high degree of suspicion to avoid delay in initiation of treatment.

Item Type: Article
Uncontrolled Keywords: Plasma cell neoplasm, Clonal proliferation, Initial presentation
Subjects: Medicine > KMC Mangalore > Pathology
Depositing User: KMCMLR User
Date Deposited: 19 Nov 2015 15:17
Last Modified: 19 Nov 2015 15:17
URI: http://eprints.manipal.edu/id/eprint/144580

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