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Radiosensitization of a mouse melanoma by withaferin A : In vivo studies

Devi, Uma P and Kamath, Ravindra and Rao, Satish BS (2000) Radiosensitization of a mouse melanoma by withaferin A : In vivo studies. Indian Journal of Experimental Biology, 38 (5). pp. 432-437.

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Abstract

The radiosensitizing effect of a plant withanolide, withaferin A, on the B16F1 mouse melanoma was studied in vivo. Treatment of 100 mm3 tumours with 10 to 60 mg/kg withaferin A intraperitoneally produced a dose dependent increase in growth delay and volume doubling time. Injection of 30-50 mg/kg withaferin A, followed by 30 Gy local gamma irradiation, significantly enhanced the tumour response. No systemic or local adverse reactions were noted in these groups. The drug was most effective when injected intraperitoneally 1 h before irradiation. However, neither the individual agents nor their combination could produce any complete response (tumour cure). Melanoma is a relatively radioresistant tumour. The present results indicate that the radiation response of this tumour can be significantly enhanced by pretreatment with withaferin A.

Item Type: Article
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 24 Nov 2015 15:26
Last Modified: 24 Nov 2015 15:26
URI: http://eprints.manipal.edu/id/eprint/144601

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