Synthesis, Characterization and Antimicrobial Activities of Some Novel Thiazoles and Thiazolo-[3,2-b]-[1,2,4]-triazole Derivatives

Shenoy, Shalini (2015) Synthesis, Characterization and Antimicrobial Activities of Some Novel Thiazoles and Thiazolo-[3,2-b]-[1,2,4]-triazole Derivatives. Journal of Applicable Chemistry, 4 (3). pp. 828-839. ISSN 2278-1862

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Abstract

The reaction of 2-(aryloxymethyl) benzo thioamide with various substituted phenacyl bromides afforded 2-[2-(aryloxymethyl)-phenyl]-N′-[4-(aryl)-thiazol-2yl]-benzohydrazide derivatives. The benzothiamide is prepared from corresponding hydrazide in KSCN/HCl in methanol. Substituted thiazolo-[3,2-b]-[1,2,4]-triazole derivatives were synthesized by a condensation reaction of the one pot three component reaction of substituted aromatic aldehydes and monochloroacetic acid in acetic acid in the presence of acetic anhydride and anhydrous sodium acetate with 5-{2-[(aryloxymethyl)-methyl]-phenyl}-4H-[1,2,4]-triazole-3-thiol. All structures of the newly synthesized compounds were elucidated by elemental analysis and spectral data. The new compounds have been tested for their in vitro antimicrobial activities. However, they shown moderate to good antimicrobial activity. Among the tested compounds 3h, and 5d shown significant antibacterial activity while 3d, 3h and 5d shown significant antifungal activity.

Item Type: Article
Uncontrolled Keywords: Multi component reaction, [1,2,4]-Triazole-5-thione, Antimicrobial activity, 2-(aryloxy methyl) phenyl moiety.
Subjects: Medicine > KMC Mangalore > Microbiology
Depositing User: KMCMLR User
Date Deposited: 27 Nov 2015 12:24
Last Modified: 27 Nov 2015 12:24
URI: http://eprints.manipal.edu/id/eprint/144619

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