Potential role of vitamin d deficiency in nonalcoholic steatosis

*, Sudha K and *, Reshma Kumarachandra and *, Souparnika S (2015) Potential role of vitamin d deficiency in nonalcoholic steatosis. International Journal of Pharma and Bio Sciences, 6 (4). (B) 133-(B) 137. ISSN 0975-6299

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Hypovitaminosis D is a wide spread and largely under recognizedpresent day epidemic. Since vitamin D undergoes activation in the liver, hepatic steatosis thought to be caused primarily due to insulin resistance can play a role in vitamin D deficiency. Hence the present study was conducted in 75 adult non diabetic patients in the age group of 25-55(45 males, 30 females) with hepatic steatosis. Liver function tests were estimated in the plasmaspectrophotometrically. Vitamin D was determined by ECLIA. Study groups included vitamin D deficient (group I), insufficient (group II) and sufficient groups (group III). Plasma ALT , ALP and total bilirubin levels were significantly higher in group I and II compared to group III patients. However, AST/ALT ratio was significantly higher groupIII compared to others. Plasma bilirubin and ALT showed significant negative correlation with vitamin D (r=-0.553,p=0.01) and AST/ALT ratio showed a positive correlation. The inverse association of vitamin D and hepatic markers attributes a possible hepatoprotective role of vitamin D. Patients with risk of impaired liver function need to be screened for vitamin D deficiency and its supplementation may prove beneficial.

Item Type: Article
Uncontrolled Keywords: VitaminD,Steatosis, Liver function tests
Subjects: Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 28 Nov 2015 15:50
Last Modified: 28 Nov 2015 15:50
URI: http://eprints.manipal.edu/id/eprint/144628

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