Thada, Smitha Rani and Vineetha, R and Pai, Keerthilatha M (2015) Generalised Fibrotic Gingival Enlargement in a Psoriatic Patient: An Association or a Coincidence? BMJ Case Report. pp. 1-5. ISSN 1757-790X
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Abstract
Gingival fibromatosis is a rare, benign, slow progressive fibrous overgrowth of gingiva, with great genetic and clinical heterogeneity. It can be inherited as an isolated trait (hereditary/idiopathic gingival fibromatosis), and/or as a component of a syndrome. We report a case of a young girl suffering from psoriasis who also presented with an unusual generalised idiopathic gingival fibromatosis. Psoriasis, a chronic inflammatory skin disease, of multifactorial origin, is characterised by keratinocyte hyperproliferation, dedifferentiation, neoangiogenesis and inflammation. T cell-mediated immunity is considered to be the key element in the disease process. The existence of oral mucosal alterations in patients with psoriasis is a controversial topic, as histopathological correlations are not clearly evident, and oral and cutaneous lesions do not follow a parallel course. However, this article highlights a possible association of T-lymphocyte stimulation inducing fibroblasts to undergo epidermal hyperproliferation and increased collagen production in the gingiva, which in turn may be responsible for inducing gingival hyperplasia.
Item Type: | Article |
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Subjects: | Dentistry > MCODS Manipal > Oral Medicine and Radiology |
Depositing User: | KMC Library |
Date Deposited: | 03 Dec 2015 16:11 |
Last Modified: | 03 Dec 2015 16:37 |
URI: | http://eprints.manipal.edu/id/eprint/144674 |
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