Oxidative Stress in Obese Postmenopausal Women: An Additive Burden for Atherosclerosis

Holla, Ramesh and Bhat, Rajesh U and *, Unnikrishnan B and *, Mukund Prathathivadibhayankaram Srinivasan (2015) Oxidative Stress in Obese Postmenopausal Women: An Additive Burden for Atherosclerosis. Journal of Clinical and Diagnostic Research, 9 (12). pp. 3-5. ISSN 0973-709X

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Abstract

Introduction: Coronary Artery Disease are on the rise in the general population and is the leading cause of death in both men and women. The impact of CAD is underappreciated in younger women when compared to men. Women have unique risk factors for CAD and postmenopausal women are at higher risk of developing CAD when compared to normal menstruating women. Aim: The aim of our study was to find out the difference in oxidative stress levels between obese postmenopausal women and normal menstruating women, also to compare the same in normal weight postmenopausal women. Materials and Methods: Thirty one normal and 29 obese postmenopausal women with age more than 45 years who visited obstetrics and gynaecology outpatient department for general clinical evaluation at a tertiary care centre were recruited in this cross-sectional study. Thirty normal menstruating women were compared. Anthropometric measurements were recorded and the body mass index was calculated. Serum Malondialdehyde and superoxide dismutase was measured using a spectrophotometer. Results: There was a significant difference in mean MDA levels in postmenopausal women (1.477 ± 0.359) when compared to normal menstruating women (0.666 ± 0.302) (p < 0.01). There was no significant difference in mean SOD levels in postmenopausal women (2.836 ± 0.899) when compared to normal menstruating women (2.986 ± 0.686) (p > 0.05). Also, there was a significant increase between mean MDA levels in obese postmenopausal women (2.48 ± 0.52) when compared to normal weight postmenopausal women (1.65 ± 0.36) (p < 0.01). There was a significant difference between mean SOD levels in obese postmenopausal women (1.36 ± 0.96) and normal weight postmenopausal women (2.56 ± 1.03) (p < 0.01). Conclusion: The oxidative stress was higher in obese postmenopausal women when compared to normal weight postmenopausal women and normal menstruating women.

Item Type: Article
Uncontrolled Keywords: Coronary artery disease, Cardiac risk factor
Subjects: Medicine > KMC Mangalore > Cardiology
Medicine > KMC Mangalore > Community Medicine
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 05 Dec 2015 16:05
Last Modified: 05 Dec 2015 16:05
URI: http://eprints.manipal.edu/id/eprint/144703

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