Critical biomarkers of epithelial‑mesenchymal transition in the head and neck cancers

Natarajan, Jayalakshmi and Chandrashekar, Chetana and Radhakrishnan, Raghu (2014) Critical biomarkers of epithelial‑mesenchymal transition in the head and neck cancers. Journal of Cancer Research and Therapeutics, 10 (3). pp. 512-518.

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Epithelial‑mesenchymal transition (EMT), a key developmental program has been shown to occur in wound healing, organ fibrosis and in the initiation of metastasis for cancer progression. EMT is a process that describes the development of motile, mesenchymal‑like cells from non‑motile parent epithelial cells. Plasticity of the cells enable significant changes in cell phenotypes and this process is governed by the interplay among different functional classes of regulatory molecules. The process typically involves the control of specific gene expression programs with distinct functional impacts on the behavior of cells. An important feature of cellular plasticity, EMT has in the recent times attracted broad interest in the field of cancer research, tumor invasion and metastases. A complete understanding of the molecular events of EMT and a search for novel molecular regulators is required for prospective targets for therapeutic interventions. This review summarizes the critical biomarkers of EMT in the head and neck cancers.

Item Type: Article
Uncontrolled Keywords: Biomarkers; epithelial‑mesenchymal transition; head and neck cancer.
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Depositing User: KMC Library
Date Deposited: 10 Dec 2015 08:58
Last Modified: 10 Dec 2015 08:58

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