Interventions for dialysis patients with hepatitis C virus (HCV) infection (Review)

Prabhu, Ravindra A and Nair, Sreekumaran N and Pai, Ganesh and Reddy, Nageswara Pammidi and Suvarna, Deepak (2015) Interventions for dialysis patients with hepatitis C virus (HCV) infection (Review). The Cochrane Collaboration (8). pp. 1-77.

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Abstract

Background :Hepatitis C virus (HCV) infection is common in chronic kidney disease (CKD) patients on dialysis, causes chronic liver disease, increases mortality and impacts kidney transplant outcomes. Sustained response to the preferred treatment with standard or pegylated (PEG) interferon is seen in 39% with side effects necessitating treatment discontinuation in 20%. We collated evidence for treatment response and harms of interventions for HCV infection in dialysis. Objectives : We aimed to look at the benefits and harms of various interventions for HCV infection in CKD patients on HD or peritoneal dialysis, specifically on mortality, disease relapse, response to treatment, treatment discontinuation, time to recovery, quality of life, cost effectiveness,adverse effects, and other outcomes. We aimed to study comparisons of available interventions with a placebo or control group, combinations of interventions with placebo or control group, interventions with each other singly and in combination, available standard interventions with newer treatment modalities. Search methods : We searched Cochrane Kidney and Transplant’s Specialised Register to 24 March 2015 through contact with the Trials’ Search Coordinator. We also checked references of reviews, studies and contacted study authors to identify additional studies. Selection criteria : Randomised controlled trials (RCTs), quasi-RCTs, first period of randomised cross-over studies on interventions for HCV in CKD on dialysis were considered. Data collection and analysis : We used standard methodological procedures expected by the Cochrane Collaboration and also collected adverse effects data listed in included RCTs.

Item Type: Article
Additional Information: Intervention Review
Subjects: Departments at MU > Statistics
Medicine > KMC Manipal > Gastroenterology
Medicine > KMC Manipal > Nephrology
Depositing User: KMC Library
Date Deposited: 10 Dec 2015 09:02
Last Modified: 10 Dec 2015 09:02
URI: http://eprints.manipal.edu/id/eprint/144731

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