Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis

Patel, Pratik and Thennavan, Aatish and Sen, Subhalakshmi and Chandrashekar, Chetana and Radhakrishnan, Raghu (2015) Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis. Journal of Oral Science, 57 (3). pp. 169-176.

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Abstract

About 20% of the world’s population uses some form of betel nut, which suggests that the incidence of oral submucous fibrosis (OSF) is higher than current estimates. OSF has the potential to undergo malignant transformation; thus, there is a need to identify relevant markers to assess its aggressiveness. We evaluated changes in COX-2, p53, and MDM2 expressions in progressive OSF. Expressions of COX-2, p53, and MDM2 increased with OSF progression. There was a strong association between COX-2 overexpression and recurrence of oral squamous cell carcinoma (P < 0.001) and a positive relation between increased MDM2 expression and failure of radiotherapy (P = 0.007). These findings suggest that COX-2 is an important marker of disease progression and that MDM2 expression is useful for treatment planning.

Item Type: Article
Uncontrolled Keywords: Oral submucous fibrosis; COX-2; p53; MDM2.
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Depositing User: KMC Library
Date Deposited: 10 Dec 2015 09:03
Last Modified: 10 Dec 2015 09:03
URI: http://eprints.manipal.edu/id/eprint/144732

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