Molecular identification and in-vitro antifungal susceptibility of fusarium sp. ssolated from corneal scrape

Peralam Yegneswaran, Prakash (2011) Molecular identification and in-vitro antifungal susceptibility of fusarium sp. ssolated from corneal scrape. Journal of Life Sciences, 3 (2). pp. 127-130.

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Abstract

Keratomycosis can have deleterious effect to human eye and may lead to loss of vision. Fungal keratitis caused by a Fusarium species was isolated and described. The isolate was identified to be Fusarium solani and confirmed by molecular data based on ITS rDNA sequence. The fungal isolate was evaluated for its antifungal susceptibility against five common antifungal agents. The result indicated that miconazole was highly sensitive but fluconazole and ketoconazole were intermediately sensitive. Amphotericin B was found to be effective against the pathogen with MIC value of 4mg/L. Human pathogenic F. solani is highly diverse and resistant to many antifungal agents. Therefore, accurate identification and susceptibility profile of this species is very essential for rapid diagnosis and treatment.

Item Type: Article
Uncontrolled Keywords: Corneal Scrape; Fusarium Solani; Molecular Identification; Antifungal Susceptibility.
Subjects: Medicine > KMC Manipal > Microbiology
Depositing User: KMC Library
Date Deposited: 16 Dec 2015 11:31
Last Modified: 16 Dec 2015 11:31
URI: http://eprints.manipal.edu/id/eprint/144816

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