Synthesis of novel 2-alkyl-4-yl-N-(5-thiophen-2-ylmethyl-[1,3,4]thiadiazol-2-yl)- acetamide derivatives as potent local anaesthetic agents

Shetty, Nitinkumar S and Shashidhar, N and Badiger, Naveen P (2015) Synthesis of novel 2-alkyl-4-yl-N-(5-thiophen-2-ylmethyl-[1,3,4]thiadiazol-2-yl)- acetamide derivatives as potent local anaesthetic agents. International Journal of Chemical and Pharmaceutical Sciences, 6 (1). pp. 41-45. ISSN 0976-9390

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Abstract

Various 2-alkyl-4-yl-N-(5-thiophen-2-ylmethyl-[1,3,4]thiadiazol-2-yl)-acetamides (3a-f) were synthesized from condensation of secondary amines with 2-chloro-N-(5-thiophen-2- ylmethyl-[1,3,4]thiadiazol-2-yl)-acetamide(2).Structures of all the newly synthesized compounds were established by analytical and spectral data. All the newly synthesized final compounds were screened for their local anaesthetic activity using the rat sciatic nerve model

Item Type: Article
Uncontrolled Keywords: 2-amino [1,3,4] thiadiazole, Chloroacetylation, Local anaesthetic agents.
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 18 Dec 2015 14:33
Last Modified: 18 Dec 2015 14:33
URI: http://eprints.manipal.edu/id/eprint/144873

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