Formulation and Characterisation of Nanosuspensions of BCS class II and IV drugs by Combinative Method

Attari, Zenab and Kalvakuntla, Sunethra and Reddy, Sreenivasa M and Rao, Mallikarjuna C and Koteshwara, KB (2016) Formulation and Characterisation of Nanosuspensions of BCS class II and IV drugs by Combinative Method. Journal of Experimental Nanoscience, 11 (4). pp. 276-288. ISSN 1745-8099

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Abstract

Drug nanocrystals are known to increase the solubility of Biopharmaceutics Classification System (BCS) class II and IV drugs. SmartCrystals are the second generation nanocrystals with particle size of less than 100 nm and increased the stability and solubility of drug and drug product. The combinative methods adopted for the preparation of SmartCrystals are reported to shorten the processing time to reduce the particle size of the drug. This study was carried out with the aim to prepare nanosuspensions of aprepitant and ibuprofen using two pretreatment methods, precipitation and ball milling in a combination of highpressure homogenisation (HPH). Ball milling and precipitation resulted in nanosuspensions having a particle size less than 1 m, which were subjected to high HPH. HPH further led to a reduction in the particle size. However, the precipitation method failed to reduce the size of ibuprofen particles to 1 m.

Item Type: Article
Uncontrolled Keywords: Ball milling; High-pressure homogenisation; Nanocrystals; Nanosuspension; Precipitation
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 07 Jan 2016 09:53
Last Modified: 07 Jan 2016 09:53
URI: http://eprints.manipal.edu/id/eprint/145020

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