Biomechanical, Biochemical and Histological Evidences for Wound Healing Properties of Indian Traditional Medicines

Kotian, Sushma R and Pai, Sreedhara KR and Bangera, Hemalatha and Keerthana, Prasad and Bhat, Kumar MR (2015) Biomechanical, Biochemical and Histological Evidences for Wound Healing Properties of Indian Traditional Medicines. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (11). pp. 163-171. ISSN 0975-1491

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Abstract

Objective: Ayurveda, India's traditional medicinal system is a rich source of natural remedies, frequently used as home and folk medicine in wound healing due to easy availability and affordability. Honey, Ghee and roots of Glycyrrhiza glabra are effectively used in Ayurveda for treating wounds of various types. Nerium indicum (a folk medicine) is also a known healing agent. Even though the known end result of these medications is faster wound healing, the mechanism of actions at tissue level, changes in the micro-environment of the wound and quantification of the rate of healing is not explored and documented using modern scientific methods. Methods: Healthy Wistar rats were used for incision wound model. Wounds were inflicted and the treatment plan was followed with regular topical application of test materials. The nature of healing was observed regularly and photographed. At different interval of the treatment plan-biomechanical, biochemical and histological studies were carried out. An attempt was also m de to quantify the microscopic changes at the wound site. Results: Faster healing was observed in all the animals treated with test materials. This was indicated by alterations in the nature of epithelisation, inflammatory changes, fibroblast recruitment and activity, fibrous composition and arrangement at the wound site in comparison with untreated group. Conclusion: The present study is useful in exploring the mechanism of action of these traditional Indian medicinal systems–Ayurveda and folk medicine and thereby provides scientific evidences for the same.

Item Type: Article
Uncontrolled Keywords: Wound healing; Honey; Ghee; Glycyrrhiza glabra; Nerium indicum
Subjects: Medicine > KMC Manipal > Anatomy
Information Sciences > MCIS Manipal
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 08 Jan 2016 11:39
Last Modified: 08 Jan 2016 11:39
URI: http://eprints.manipal.edu/id/eprint/145035

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