Modulation of genetic clusters for synthesis of bioactive molecules infungal endophytes: A review

Deepika, VB and Murali, TS and Satyamoorthy, K (2016) Modulation of genetic clusters for synthesis of bioactive molecules infungal endophytes: A review. Microbiological Research, 182. pp. 125-140. ISSN 0944-5013

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Novel drugs with unique and targeted mode of action are very much need of the hour to treat andmanage severe multidrug infections and other life-threatening complications. Though natural moleculeshave proved to be effective and environmentally safe, the relative paucity of discovery of new drugs hasforced us to lean towards synthetic chemistry for developing novel drug molecules. Plants and microbesare the major resources that we rely upon in our pursuit towards discovery of novel compounds ofpharmacological importance with less toxicity. Endophytes, an eclectic group of microbes having thepotential to chemically bridge the gap between plants and microbes, have attracted the most attentiondue to their relatively high metabolic versatility. Since continuous large scale supply of major metabolitesfrom microfungi and especially endophytes is severely impeded by the phenomenon of attenuation inaxenic cultures, the major challenge is to understand the regulatory mechanisms in operation that drivethe expression of metabolic gene clusters of pharmaceutical importance. This review is focused on themajor regulatory elements that operate in filamentous fungi and various combinatorial multi-disciplinaryapproaches involving bioinformatics, molecular biology, and metabolomics that could aid in large scalesynthesis of important lead molecules.

Item Type: Article
Uncontrolled Keywords: Endophytes; secondary metabolites; orphan gene clusters; gene activation; attenuation; regulation.
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 15 Jan 2016 08:50
Last Modified: 15 Jan 2016 08:50

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