Influence of Zincovit Drop (nutritional food supplement) on Immune System in Normal and Cyclophosphamide Intoxicated Wistar Rats

Satyam, Shakthi Mani and Bairy, Laxminarayana K (2016) Influence of Zincovit Drop (nutritional food supplement) on Immune System in Normal and Cyclophosphamide Intoxicated Wistar Rats. Asian Journal of Pharmaceutical and Clinical Research, 9 (1). pp. 238-240. ISSN 0974-2441

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Abstract

Objective: The aim of the present study was to investigate the influence of Zincovit (ZVT) drop (nutritional food supplement) on the immune system in normal healthy and cyclophosphamide(Cp) intoxicated rats.Mrthods:The study was carried out in healthy and immunotixic wistar rats (CP;20 mg/kg/day) with ZVT drop (a combined formulation of multivitamin -multimineral, flaxseed, oil and lysine) at the dose of 25 mg/ kg/ day for 45 days.Hematological and immunological parameters, such as immunoglobilin(Ig) G,iGm, interferon-y,interleukin- 2, and interlekukin-4, were assessed.In addition hostopathological examination of the spleen was also performed. Result: There were no significant changes in all th hematological parameters such as total leukocyte, different leukocyte,total erythrocyte and total platelets count,hemoglobin amount and slso the immunological parameters such as Igm,interferson-y and interleukin-4 level among the treatment groups except interleukin-2.there was a signifiant increae in interleukin-2 level in the group of animals treated with ZVT drop at the dose of 25 mg/kg(p<0.001)and 50 mg/kg (p<0.05) in comparison with normal control animals. Conclusion;The present study revealed the immunomodulatory effect of ZVT drop at the dose of 25 and 50 mg/kg/day in normal healthy wistar rats.

Item Type: Article
Uncontrolled Keywords: Zincovit drop; Flax seed oil; Multivitamin-multimineral nutritional food Suppliment; Cyclophosphaminde; Immunomodulatory
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 03 Feb 2016 13:44
Last Modified: 03 Feb 2016 13:44
URI: http://eprints.manipal.edu/id/eprint/145172

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