Fatal poisoning with colchicum autumnale: A case report

Rao, Raghavendra and Seshadri, Shubha and Seshadri, Sneha and Patil, Navin and Rao, Karthik and Nayak, Vinod C and Dsouza, Haniel Larson and Jaunky, Chaitan (2016) Fatal poisoning with colchicum autumnale: A case report. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7 (1). pp. 1760-1762. ISSN 0975-8585

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Abstract

Colchicum autumnale is commonly known as the autumn crocus, wild saffron and naked lady. In local language here in southern Karnataka, it is known as gowri gedde. It contains alkaloid colchicine that is antimitotic, blocking the mitosis by preventing DNA synthesis and tubulin polymerization. The clinical manifestation of colchicine poisoning is present in three phases following a latent period of 4-12 hours. The first phase is characterized by peripheral leukocytosis, gastrointestinal symptoms with fluid losses and hypovolemic shock. During 24-72 hours, the second stage of intoxication, life threatening complications occur such as arrhythmias, heart failure, renal failure, hepatic injury, respiratory distress, coagulopathies, bone marrow suppression and neuromuscular involvement. Second phase usually lasts for 5-7 days. Third phase is characterized by leukocytosis and alopecia. Colchicine is rapidly absorbed from the gastrointestinal tract and is primarily metabolized in the liver in a first order process. There is also significant biliary excretion and enterohepatic recirculation. Renal excretion is only responsible for about 20% of unchanged colchicine elimination. We present here a case of fatal poisoning with colchicum autumnale in a middle aged lady who finally succumbed to death due to multi-organ dysfunction.

Item Type: Article
Uncontrolled Keywords: Fatal; poisioning; colchicum autumnale.
Subjects: Medicine > KMC Manipal > Forensic Medicine
Medicine > KMC Manipal > Medicine
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 04 Feb 2016 08:57
Last Modified: 04 Feb 2016 08:57
URI: http://eprints.manipal.edu/id/eprint/145192

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