Endometrial Intraepithelial Neoplasia And Its Correlation With WHO Classified Endometrial Hyperplasia

Khanna, R and Khanna, Vinay (2010) Endometrial Intraepithelial Neoplasia And Its Correlation With WHO Classified Endometrial Hyperplasia. The Internet Journal of Pathology, 12 (1). pp. 1-4. ISSN 1528-8307

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Introduction: Endometrial hyperplasia produces a continuum of lesions that may be precursor to endometrial carcinoma of endometrioid histology. The World Health Organization (WHO) classification is currently the most commonly accepted system of classifying endometrial hyperplasias, the problems with which have prompted the development of an alternative system based on Endometrial Intraepithelial Neoplasia (EIN).Materials and Methods: We undertook the study using revised EIN criteria to differentiate EIN lesions from lookalikes. EIN diagnostic criteria’s, such as gland area>stromal area, cytologic change in focus of altered architecture, lesion size>1 mm and exclusion of cancer and mimics were applied on two hundred endometrial biopsies that were initially classified as hyperplasia using WHO classification system.Results: Out of total two hundred cases, 41.5% were diagnosed as simple typical hyperplasia, 19% cases as complex typical hyperplasia, 9.5% cases as simple atypical hyperplasia and 30% cases as comple atypical hyperplasia respectively. Out of these WHO classified hyperplasias, 39% were re-classified as EIN and 61% as non-EIN lesions. Majority of WHO classified atypical hyperplasias were reclassified as EIN.Conclusion: EIN criterias can easily be applied to routine haematoxylin and eosin stained sections and is more reproducible than WHO system of classification. Few of the lesions diagnosed as simple hyperplasia without atypia correspond to EIN and have a worse prognosis. EIN successfully segregates patients into high and low cancer risk groups.

Item Type: Article
Subjects: Medicine > KMC Manipal > Pathology
Depositing User: KMC Library
Date Deposited: 10 Feb 2016 09:15
Last Modified: 10 Feb 2016 09:15
URI: http://eprints.manipal.edu/id/eprint/145288

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