Selection of cryoprotective agent for freeze drying of valsartan solid lipid nanoparticles

Kumar, Lalit and Reddy, Meka Sreenivasa and Verma, Ruchi and Koteshwara, KB (2016) Selection of cryoprotective agent for freeze drying of valsartan solid lipid nanoparticles. Latin American Journal of Pharmacy, 35 (2). pp. 284-290. ISSN 0326 2383

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The aim of the present study was to select the cryoprotective agent for valsartan solid lipid nanoparticles. The cryoprotective agents were mixed with prepared nanoemulsion and lyophilized for 24h. The cryoprotective agent and its concentration were selected on the basis of particle size, polydispersity index and zeta potential. The stability of prepared nanoparticles (with and without cryoprotective agents) was also determined in respect of particle size and polydispersity index. The cryoprotective agents showed their effect in the following order: mannitol > lactose > sorbitol > maltose > glucose > sucrose > PVP > fructose > starch > dextrose. The particle size, PDI and zeta potential of the nanoformulations containing 10 % mannitol was found to be 403 nm, 0.39 and -19.27 mV, respectively. Six months accelerated stability study data does not show any significant effect (at p > 0.05) of temperature on the lyophilized nanoformulations. The present study concludes that the mannitol is a very good cryoprotective agent to retain the small particle size and least PDI value of valsartan nanoformulations even at temperatures of 30 and 40 °C.

Item Type: Article
Uncontrolled Keywords: Cryoprotective agents; freeze-drying; glyceryl monostearate; lipid nanoparticles; valsartan.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 10 Feb 2016 09:25
Last Modified: 10 Feb 2016 09:25

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