Naringin and rutin alleviates episodic memory deficits in two differentially challenged object recognition tasks

Ramalingayya, Grandhi Venkata and Nampoothiri, Madhavan and Nayak, Pawan G and Kishore, Anoop and Shenoy, Rekha R and Rao, Mallikarjuna C and Nandakumar, K (2016) Naringin and rutin alleviates episodic memory deficits in two differentially challenged object recognition tasks. Pharmacognosy Magazine, 12 (45 S-1). S-63. ISSN 0973-1296

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Abstract

Background: Cognitive decline or dementia is a debilitating problem of neurological disorders such as Alzheimer’s and Parkinson’s disease, including special conditions like chemobrain. Dietary flavonoids proved to be efficacious in delaying the incidence of neurodegenerative diseases. Two such flavonoids, naringin (NAR) and rutin (RUT) were reported to have neuroprotective potential with beneficial effects on spatial and emotional memories in particular. However, the efficacy of these flavonoids is poorly understood on episodic memory, which comprises an important form of autobiographical memory. Objective: This study objective is to evaluate NAR and RUT to reverse time‑delay‑induced long‑term and scopolamine‑induced short‑term episodic memory deficits in Wistar rats. Materials and Methods: We have evaluated both short‑term and long‑term episodic memory forms using novel object recognition task. Open field paradigm was used to assess locomotor activity for any confounding influence on memory assessment. Donepezil was used as positive control and was effective in both models at 1 mg/kg, i.p. Results: Animals treated with NAR and RUT at 50 and 100 mg/kg, p.o. spent significantly more time exploring novel object compared to familiar one, whereas control animals spent almost equal time with both objects in choice trial. NAR and RUT dose‑dependently increased recognition and discriminative indices in time‑induced long‑term as well as scopolamine‑induced short‑term episodic memory deficit models without interfering with the locomotor activity. Conclusion: We conclude that, NAR and RUT averted both short‑ and long‑term episodic memory deficits in Wistar rats, which may be potential interventions for neurodegenerative diseases as well as chemobrain condition.

Item Type: Article
Uncontrolled Keywords: Alzheimer’s disease; chemobrain; cognition; episodic memory; flavonoids; neurodegenerative disease; novel object recognition task.
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 12 Feb 2016 15:56
Last Modified: 12 Feb 2016 15:56
URI: http://eprints.manipal.edu/id/eprint/145318

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