Demographics, clinical characteristics, treatment and outcomes of acute rgano-phosphorous pesticide poisoning from South India

Puppala, Geetika Krishna and Thunga, Girish and Chekka, Manasa and Vidyasagar, Sudha and Vijayanaryana, K and Sreedharan, N and Shetty, Prasanna Kumar (2015) Demographics, clinical characteristics, treatment and outcomes of acute rgano-phosphorous pesticide poisoning from South India. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6 (6). pp. 826-834. ISSN 0975-8585

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Abstract

Organophosphate poisoning is a major clinical problem causing 200,000 deaths annually. Case fatality of intentional-poisoning in developing countries is as high as 10-20%, due to the high toxicity of available pesticides, and lack of proper evidence for the use of standard treatments. This study is aimed to review the demographics, characteristics, treatment and outcomes of OP poisoning. Patients with clinical diagnosis of acute OP poisoning, admitted between February 2009 and November 2012 were followed prospectively. Chronic exposures of OP, unknown or mixed poisons were excluded. In 256 subjects, Mean age was 33.44 ± 13.55 years, Males constituted 53.5%. Maximum poisons belonged to WHO class I toxicity, most common was Methyl Parathion. Median pseudocholinesterase level was 290±1987 (median ± IQR). Severity at the time of admission was assessed using GCS: 12± 6 (median ± IQR), PSS: 2± 1 (median ± IQR) and APACHE-II scores: 17± 27 (median ± IQR). Higher the severity of poisoning lower was the cholinesterase level. 232 (91%) patients received gastric lavage. 62 (24.2%) received atropine and glycopyrrolate. 230 (89.8%) received pralidoxime. There was no significant effect of gastric lavage or charcoal administration on the outcome. Hospitalization duration was reduced in atropine and glycopyrrolate group compared to atropine alone.

Item Type: Article
Uncontrolled Keywords: OP Poisoning; demographics; treatment; outcomes; pralidoxime; glycopyrrolate.
Subjects: Medicine > KMC Manipal > Medicine
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Library
Date Deposited: 12 Feb 2016 15:58
Last Modified: 12 Feb 2016 15:58
URI: http://eprints.manipal.edu/id/eprint/145322

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