Atypical presentation of metoclopramide-induced galactorrhea

Menon, Parvathy and Thunga, Girish and Nambiar, Srikanth and Khera, Kanav (2015) Atypical presentation of metoclopramide-induced galactorrhea. Journal of Pharmacy Practice and Research, 45 (4). pp. 437-439.

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Background: Metoclopramide is commonly used for the management of nausea and vomiting, but is associated with a range of adverse effects, including galactorrhea. Aim: To present a case of an atypical presentation of metoclopramide-induced galactorrhea. Clinical details: A previously asymptomatic 30-year-old woman was treated with metoclopramide for management of gastrointestinal symptoms. Five days after the initiation of treatment she developed pain in both breasts and whitish discharge from nipples of both breasts, whichwassubsequently identified as milk. Herlast menstrual periodwas4 days before admission to hospital, andhad lasted only for a day. Four years prior to admission, she hadundergone a tubectomy. Transvaginal ultrasoundwasused to rule out pregnancy. Thyroid, liver and kidney function were normal, and the serum concentration of prolactin at this time was 1.8 ng/mL(reference range 3.3–26 ng/mL), slightly below the normal level. Metoclopramide was discontinued and galactorrhea, mastalgia and fever subsided. Outcomes: Metoclopramide was discontinued and galactorrhea, mastalgia and fever subsided. Conclusion: Although previous reports have described metoclopramide-induced galactorrhea in association with hyperprolactinaemia, this case appears to represent a probable atypical presentation of an adverse drug reaction.

Item Type: Article
Uncontrolled Keywords: lactorrhea; mastalgia; prolactin.
Subjects: Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Library
Date Deposited: 12 Feb 2016 08:51
Last Modified: 12 Feb 2016 08:51

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