Pulmonary Function in Type 2 Diabetes Mellitus: Correlation with Body Mass Index and Glycemic Control

Acharya, Preetam Rajgopal and D’Souza, Monalisa and *, Anand R and Kotian, Shashidhar M. (2016) Pulmonary Function in Type 2 Diabetes Mellitus: Correlation with Body Mass Index and Glycemic Control. International Journal of Scientific Study, 3 (11). pp. 18-23.

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Introduction: The lung with its large surface area and extensive vasculature is postulated to be one of the “target organs” for damage in diabetes mellitus (DM). However, changes in lung function occurring in Type 2 Diabetes Mellitus (Type 2 DM) have not been well-characterized in previous studies. Purpose: To study the pulmonary function abnormalities in patients with Type 2 DM and to find correlations with duration, body mass index, glycemic control, and nephropathy. Materials and Methods: This prospective study was conducted among Type 2 DM patients attending the diabetic clinic of a medical college hospital. 124 non-smokers with Type 2 DM, not suffering from respiratory allergies and who did not have any acute or chronic pulmonary diseases were included. Body mass index (BMI) was calculated for all patients. Glycemic control was assessed by measuring glycosylated hemoglobin (serum HBA1c). Spirometry and measurement of diffusing capacity by single-breath method (DLCO-SB) was done in all the patients. The presence of diabetic glomerulopathy was determined by checking urine samples for microalbuminuria in a subset of patients. Patients were divided into subgroups based on BMI, HBA1c levels, duration of DM and data analyzed using ANOVA and Student’s unpaired t-test. SPSS version 17.0 was used for statistical analysis. Results: A statistically significant reduction was seen in diffusing capacity with increasing duration of DM (P < 0.05). Statistically insignificant reductions were observed in forced expired volume in 1 s (FEV1), forced vital capacity (FVC), peak expiratory flow rate, (PEFR) forced expiratory flow (FEF 25%-75%) in patients with >20 years of DM in comparison to their counterparts with <10 years of DM; FEV1/FVC was found to be unimpaired in DM. Conclusions: Type 2 DM is associated with a reduction in diffusing capacity with increasing duration of disease. This reduction was not limited only to patients with microalbuminuria. BMI and level of glycemic control did not affect lung functions in diabetic patients.

Item Type: Article
Uncontrolled Keywords: Diffusing capacity, Pulmonary function, Type 2 diabetes mellitus
Subjects: Medicine > KMC Mangalore > Pulmonary Medicine
Medicine > KMC Mangalore > Community Medicine
Depositing User: KMCMLR User
Date Deposited: 23 Feb 2016 11:23
Last Modified: 23 Feb 2016 11:23
URI: http://eprints.manipal.edu/id/eprint/145389

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