Genotype and Sickle Cell Allele Frequency Distribution in a Tribal Population of India

Neha, Ghai and Gurmeet, Singh and Rais, Naushad (2015) Genotype and Sickle Cell Allele Frequency Distribution in a Tribal Population of India. Frontiers of Biological and Life Sciences, 3 (1). pp. 25-28.

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Abstract

Haemoglobinopathies such as sickle cell anaemia are the commonest hereditary disorders and a serious threat to general public health in India. It is a recessive autosomal disorder which is commonly encountered in heterozygous and ho-mozygous form in India where it is prevalent in central Deccan plateau. The present study was undertaken to establish the pre-valence of sickle cell anaemia and sickle cell trait in the tribal population of Chhattisgarh. The study included 1056 participants from tribal population of Chattisgarh, India who donated their blood samples. On the spot, solubility test was performed and the positive samples were confirmed by cellulose acetate Hb electrophoresis followed by HPLC. The data thus obtained was used to calculate the allele frequency of HbS trait among tribal population of Chhattisgarh and compared with other similar studies conducted around India. Sickle cell trait was detected in 20.2% of population whereas 1.2% was affected with sickle cell anaemia. The allele frequency of HbA and HbS alleles were 0.89 and 0.11, respectively. There was a huge deviation from the tribal population of Maharashtra, Orissa, and Gujarat. The results of this study showed the uneven distribution of tribal population throughout India and the need to make them aware of the risks associated with sickle cell anaemia. As sickle cell gene is a major component of gene pool of these tribal populations, there is an urgent need to strategize the preventive measure to reduce its prevalence among tribal population of India.

Item Type: Article
Subjects: Engineering > Dubai Campus > School of Life Sciences
Depositing User: Admin MU Dubai
Date Deposited: 02 Mar 2016 17:05
Last Modified: 02 Mar 2016 17:05
URI: http://eprints.manipal.edu/id/eprint/145467

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