The role of MMP-2 and MMP-9 as prognostic markers in the early stages of tongue squamous cell carcinoma

Aparna, Manikkath and Rao, Lakshmi and Kunhikatta, Vijayanarayana and Radhakrishnan, Raghu (2015) The role of MMP-2 and MMP-9 as prognostic markers in the early stages of tongue squamous cell carcinoma. Journal of Oral Pathology & Medicine, 44 (5). pp. 345-352. ISSN 1600-0714

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Abstract

BACKGROUND: Tongue cancer is the most common intra-oral malignancy with a high rate of morbidity and mortality owing to its increased propensity for tumor invasion and metastasis. These processes require a controlled degradation of the extracellular matrix. Matrix Metalloproteinase-2 (MMP-2) and Matrix Metalloproteinase- 9 (MMP-9) are known to be important regulators of matrix lysis and play a significant role in the metastasis of malignancies. AIM AND OBJECTIVES: To study the expression of MMP-2 and MMP-9 in the early stages of tongue squamous cell carcinoma and find the association between their expression and local recurrence, metastasis, and survival rates of the subjects. MATERIALS AND METHODS: Fifty-nine tumor biopsy samples of tongue squamous cell carcinoma in T1N0M0 and T2N0M0 stageswereimmunostainedwithMMP-2 andMMP- 9 antibodies. The immunohistochemical expression was compared with the patient characteristics and outcome. RESULTS: Cytoplasmic expression of MMP-2 correlated with that of MMP-9 (r = 0.716, P < 0.001). Greater expression of MMP-2 and MMP-9 was observed in patients who subsequently developed local recurrence (P = 0.044 and P < 0.001, respectively), regional and/or distant metastasis (P < 0.001 and P = 0.001, respectively) of the tumor. Further, a higher expression of these biomarkers was associated with shorter survival. MMP-9 was found to have better specificity for local recurrence, metastasis and survival. CONCLUSION: Our results showed that these biomarkers may serve as indicators of a patient’s risk potential for poor prognosis and presage the need for more aggressive treatment measures.

Item Type: Article
Uncontrolled Keywords: Early stages; immunohistochemistry; matrix metalloproteinases; prognosis; tongue cancer.
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Medicine > KMC Manipal > Pathology
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Library
Date Deposited: 09 Mar 2016 08:54
Last Modified: 09 Mar 2016 08:54
URI: http://eprints.manipal.edu/id/eprint/145509

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