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Synthesis of new 4[4-(4-nitrophenoxy)phenyl]-5- substituted-2H-1,2,4-triazole-3-thiones and their evaluation as anthelmintics

Namratha, B and Bilehal, Dinesh and Shyamkumar, V and Gaonkar, Santosh L (2016) Synthesis of new 4[4-(4-nitrophenoxy)phenyl]-5- substituted-2H-1,2,4-triazole-3-thiones and their evaluation as anthelmintics. Research on Chemical Intermediates, 42 (3). pp. 1885-1897. ISSN 0922-6168

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Abstract

A library of novel 4-[4-(4-nitrophenoxy)phenyl]-5-substituted-2H-1,2,4- triazole-3-thiones containing different substituents at the 5-position is synthesized. The mechanochemical treatment is followed to synthesize target compounds 8 (a– p), and the yields are compared by both the grinding method and the conventional method. The structure of the intermediate, isothiocyanato 4-(4-nitrophenoxy)benzene 6, is analyzed by single crystal X-ray studies. The title compounds are characterized by spectral and elemental analyses and further evaluated for their efficacy as anthelmintics in vitro. Compounds 8c, 8j, 8k, 8l, and 8m exhibit significant anthelmintic activity

Item Type: Article
Uncontrolled Keywords: Anthelmintic � Grinding � Nitroscanate � Triazole
Subjects: Engineering > MIT Manipal > Biotechnology
Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 15 Mar 2016 10:58
Last Modified: 15 Mar 2016 10:58
URI: http://eprints.manipal.edu/id/eprint/145554

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