Managing Odds in tem Cells: Insights into the Role of Mitochondrial Antioxidant Enzyme MnSOD

Sheshadri, Preethi and Kumar, Anujith (2016) Managing Odds in tem Cells: Insights into the Role of Mitochondrial Antioxidant Enzyme MnSOD. Free Radical Research, 4 (4). pp. 1-46. ISSN 1071-5762

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Abstract

Reactive Oxygen species (ROS) has been poised at a straddled state of being beneficiary as well detrimental depending on its threshold levels. Maintaining the homeostasis of ROS is imperative for normal cellular physiology, wherein physiological concentrations of ROS is involved in cell signaling and elevated ROS contribute to the development of various diseases. Superoxide dismutases (SODs), enzymes involved in dismutation of superoxide anion to hydrogen peroxide, arrive as a first line of defense when there is perturbation in the homeostasis of ROS. As mitochondria is the main site of superoxide production, among SODs, mitochondrial manganese superoxide dismutase (MnSOD) is the primary antioxidant enzyme that protects cells from ROS. Most importantly, knockout of MnSOD lead to postnatal lethality and tissue specific conditional knockout in brain resulted in death of mice, conclusively portraying the essential role of MnSOD in development. Although MnSOD has been extensively discussed with the purview of tumor biology and aging, understanding the crucial role of MnSOD in stem cell physiology is still at its infant stage. Ever increasing progress in stem cell research have recently unveiled the essential role of MnSOD in self-renewal and differentiation of stem cells. In this review, we will conglomerate the current aspects by which MnSOD can contribute to embryonic stem cells (ESCs) and adult stem cells (ASCs) functions and interpret the necessity of understanding MnSOD for further stem cell mediated applications.

Item Type: Article
Uncontrolled Keywords: Embryonic stem cells; Reactive oxygen species; hematopoietic stem cells; oxidative phosphorylation; superoxide dismutase.
Subjects: Regenerative Medicine > MIRM Bangalore
Depositing User: MCON Library
Date Deposited: 10 Apr 2016 14:42
Last Modified: 10 Apr 2016 14:42
URI: http://eprints.manipal.edu/id/eprint/145584

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