Allogeneic and Autologous Mode of Stem Cell Transplantation in Regenerative Medicine: Which way to go?

Mamidi, Murali Krishna and Bhonde, Ramesh and Pal, Rajarshi (2014) Allogeneic and Autologous Mode of Stem Cell Transplantation in Regenerative Medicine: Which way to go? Medical Hypotheses, 83. pp. 787-791.

[img] PDF
DisplayPdf(3).aspx.pdf - Published Version
Restricted to Registered users only

Download (489kB) | Request a copy

Abstract

Stem cell transplantation is a generic term covering different techniques. However there is argument over the pros and cons of autologous and allogeneic transplants of mesenchymal stem cells (MSCs) for regenerative therapy. Given that the MSCs have already been proven to be safe in patients, we hypothesize that allogeneic transplantation could be more effective and cost-effective as compared to autologous transplantation specifically in older subjects who are the likely victims of degenerative diseases.This analysis is based on the scientific logic that allogeneic stem cells extracted in large numbers from young and healthy donors could be physiologically, metabolically and genetically more stable. Therefore stem cells from young donors may be expected to exhibit higher vigor in secreting trophic factors leading to activation of host tissue-specific stem cells and also be more efficient in remodeling the microenvironmental niche of damaged tissue

Item Type: Article
Subjects: Regenerative Medicine > MIRM Bangalore
Depositing User: KMC Library
Date Deposited: 10 Apr 2016 14:16
Last Modified: 10 Apr 2016 14:16
URI: http://eprints.manipal.edu/id/eprint/145778

Actions (login required)

View Item View Item