In Vitro and in Vivo Neurogenic Potential of Mesenchymal Stem Cells Isolated from Different Sources

Pal, Rajarshi (2014) In Vitro and in Vivo Neurogenic Potential of Mesenchymal Stem Cells Isolated from Different Sources. Journal of Biosciences, 39 (1). pp. 157-169.

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Abstract

Regenerative medicine is an evolving interdisciplinary topic of research involving numerous technological methods that utilize stem cells to repair damaged tissues. Particularly, mesenchymal stem cells (MSCs) are a great tool in regenerative medicine because of their lack of tumorogenicity, immunogenicity and ability to perform immunomodulatory as well as anti-inflammatory functions. Numerous studies have investigated the role of MSCs in tissue repair and modulation of allogeneic immune responses. MSCs derived from different sources hold unique regenerative potential as they are selfrenewing and can differentiate into chondrocytes, osteoblasts, adipocytes, cardiomyocytes, hepatocytes, endothelial and neuronal cells, among which neuronal-like cells have gained special interest. MSCs also have the ability to secrete multiple bioactive molecules capable of stimulating recovery of injured cells and inhibiting inflammation. In this review we focus on neural differentiation potential ofMSCs isolated from different sources and how certain growth factors/small molecules can be used to derive neuronal phenotypes from MSCs. We also discuss the efficacy of MSCs when transplanted in vivo and how they can generate certain neurons and lead to relief or recovery of the diseased condition.Furthermore, we have tried to evaluate the appropriatemerits of different sources ofMSCs with respect to their propensity towards neurological differentiation as well as their effectiveness in preclinical studies

Item Type: Article
Uncontrolled Keywords: Clinical trials; Mesenchymal stem cells (MSCs); Neuronal differentiation; Self-renewal
Subjects: Regenerative Medicine > MIRM Bangalore
Depositing User: MCON Library
Date Deposited: 10 Apr 2016 14:19
Last Modified: 10 Apr 2016 14:19
URI: http://eprints.manipal.edu/id/eprint/145810

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