Development of Polyvinlyl alcohol-Chitosan-Hydroxypropylmethylcellulose-based composite films for biomedical applications

Gopalakrishnan, Saran and Thakur, Goutam and Kumar, Anil N V (2016) Development of Polyvinlyl alcohol-Chitosan-Hydroxypropylmethylcellulose-based composite films for biomedical applications. In: Manipal University Students’ Research Forum, April 4-6,2016, Manipal, India.

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Abstract

A key challenge in the transdermal mode of drug delivery is the design of an optimal film that is flexible, bio-compatible, water-soluble, and has excellent mechanical strength. Previous studies have demonstrated a trade-off between biocompatibility and mechanical properties and concluded that a hybrid film containing both synthetic and biocompatible monomers is most promising for wound healing applications. In this project the focus will be on the formulation of various transdermal films of hydroxylpropylmethylcellulose, chitosan, and polyvinyl alcohol (PVA) in different ratios using the solvent casting technique. The prepared films were characterized using Fourier transform infrared (FTIR) spectroscopy and swell test to access the type of interaction occurring between the constituent polymers used and stability. FTIR Analysis revealed physical form of interactions between the polymers, which is desired for better release efficiency. It was found that the films devoid of PVA disintegrated within about 15 mins in an aqueous medium whereas those films consisting of PVA showed an improved stability in an aqueous medium. The films inclusive of all three polymers exhibit more promising results.

Item Type: Conference or Workshop Item (Paper)
Subjects: Engineering > MIT Manipal > Biomedical
Depositing User: MIT Library
Date Deposited: 26 Apr 2016 10:40
Last Modified: 26 Apr 2016 10:40
URI: http://eprints.manipal.edu/id/eprint/145921

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