Transport of Diclofenac Sodium from Composite Hydrogel

Dathathri, Eshwari and Thakur, Goutam and Koteshwara, KB (2016) Transport of Diclofenac Sodium from Composite Hydrogel. In: Manipal University Students’ Research Forum, 4-6,2016 April, Manipal, India.

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Hydrogels are a class of biomaterials which find immense biomedical application due to their useful properties such as biocompatibility, fluid retention capacity and sustained release of bioactive agents. A study was done with the objective of understanding these properties. A composite hydrogel of chitosan gelatin in the ratio 1.5:1 was formulated. Diclofenac sodium of 1% (w/w) was the model drug incorporated into the gel. Characterization of hydrogel was done by performing Swell test in deionized water for 24hrs and determining swelling index. In-vitro release of diclofenac sodium from composite hydrogel was done in deionized water for a period of 72 hours; samples analyzed at 276nm in UV Spectrophotometer and cumulative release recorded. Increase in swelling of hydrogel upto 80% in 24 hours was observed. A sustained drug release of about 56% for 72 hours was observed. This hydrogel formulation showed best fitness with Higuchi model and mechanism of release was Fickian diffusion. In conclusion, the presence of chitosan gelatin crosslinking and increased viscosity of gel enabled sustained drug release.

Item Type: Conference or Workshop Item (Paper)
Subjects: Engineering > MIT Manipal > Biomedical
Depositing User: MIT Library
Date Deposited: 26 Apr 2016 10:38
Last Modified: 26 Apr 2016 10:38

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