Recent Advances in Co-amorphous Drug Formulations

Dengale, Swapnil Jayant (2016) Recent Advances in Co-amorphous Drug Formulations. Advanced Drug Delivery Reviews, 100. pp. 116-125.

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Co-amorphous drug delivery systems have recently gained considerable interest in the pharmaceutical field because of their potential to improve oral bioavailability of poorlywater-soluble drugs through drug dissolution enhancement as a result of the amorphous nature of the material. A co-amorphous system is characterized by the use of only low molecular weight components that are mixed into a homogeneous single-phase co-amorphous blend. The use of only low molecular weight co-formers makes this approach very attractive, as the amount of amorphous stabilizer can be significantly reduced comparedwith other amorphous stabilization techniques. Because of this, several research groups started to investigate the co-amorphous formulation approach, resulting in an increasing amount of scientific publications over the last fewyears. This study provides an overview of the coamorphous field and its recent findings. In particular, we investigate co-amorphous formulations fromthe viewpoint of solid dispersions, describe t eir formation and mechanism of stabilization, study their impact on dissolution and in vivo performance and briefly outline the future potentials

Item Type: Article
Uncontrolled Keywords: Co-amorphous; Solid dispersion; Poorly soluble drugs; Molecular interactions; Increased dissolution
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Depositing User: KMC Library
Date Deposited: 10 May 2016 12:10
Last Modified: 10 May 2016 12:10

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