Smriti, Komal and Pai, Keerthilatha M and Ravindranath, Vineetha and Pentapati, Kalyana Chakravarthy (2016) Role of Salivary Malondialdehyde in Assessment of Oxidative Stress among Diabetics. Journal of Oral Biology and Craniofacial Research, 6 (1). pp. 41-44.

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Abstract

Aims: To evaluate and compare the salivary content of malondialdehyde (MDA) in patients with type 2 diabetes and control subjects.Methods: We conducted a cross-sectional study among 30 freshly diagnosed subjects of diabetes mellitus and 30 volunteers with no diabetes mellitus. Serum and salivary MDS levels were evaluated among all the subjects.Results: The mean serum MDA in group controls and diabetics was 0.95 0.13 and 3.11 0.42. The mean salivary MDA in group controls and diabetics was 0.26 0.05 mmol/l and 0.81 0.07 mmol/l. The mean serum and salivary MDA levels were significantly higher in group diabetics than control group ( p < 0.001 and <0.001) respectively. There was significant positive strong correlation between serum and salivary MDA levels in both controls and diabetics groups (r = 0.857, p < 0.001 and r = 0.891, p < 0.001) respectively.Conclusion: MDA was detectable in saliva in both diabetic and control groups. There was a positive significant correlation between salivary and serum MDA in diabeti and control subjects. Hence, salivary MDA appears to be an indicator of serum MDA concentration.

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