Bioactive PLGA–curcumin microparticle-embedded chitosan scaffold: in vitro and in vivo evaluation

Amirthalingam, Muthukumar and Kasinathan, Narayanan and Amuthan, Arul and Mutalik, Srinivas and Reddy, Sreenivasa M and Udupa, N (2016) Bioactive PLGA–curcumin microparticle-embedded chitosan scaffold: in vitro and in vivo evaluation. Artificial Cells, Nanomedicine, and Biotechnology, 44. pp. 1-10. ISSN 2169-1401

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Abstract

Wound healing is a complex process affected by several factors. In the present work, novel biocompatible PLGA–curcumin microparticle-embedded chitosan scaffold was fabricated for wound-healing application. Process variables involved in the preparation of microparticles were optimized using design of experiment. Scanning electron microscopy (SEM) confirmed the porous nature of scaffold with embedded microparticles. A maximum release of 14% of the encapsulated curcumin was observed at 12th hour. Modified tube dilution method showed that scaffold significantly (p50.05) reduced multiplication of Staphylococcus aureus. More than 50% of the excised wound in rats healed in 4 days with an epithilization period of 18 days.

Item Type: Article
Uncontrolled Keywords: Chitosan scaffold; curcumin microparticles; design of experiments; tissue regeneration; wound healing.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacology
Pharmacy > MCOPS Manipal > Pharmacy Management
Depositing User: KMC Library
Date Deposited: 18 Jun 2016 16:12
Last Modified: 18 Jun 2016 16:12
URI: http://eprints.manipal.edu/id/eprint/146372

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