Risk factors for preterm birth and low birth weight among pregnant Indian women: A hospital-based prospective study

Tellapragada, Chaitanya and Eshwara, Vandana Kalwaje and Bhat, Parvati V and Acharya, Shashidhar and Kamath, Asha and Bhat, Shashikala and Rao, Chythra and Nayak, Sathisha and Mukhopadhyay, Chiranjay (2016) Risk factors for preterm birth and low birth weight among pregnant Indian women: A hospital-based prospective study. Journal of Preventive Medicine & Public Health, 49 (3). pp. 165-175.

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Objectives: The present study was undertaken to study the maternal risk factors for preterm birth (PTB) and low birth weight (LBW) with a special emphasis on assessing the proportions of maternal genitourinary and periodontal infections among Indian women and their association with adverse pregnancy outcomes. Methods: A hospital-based prospective study comprising 790 pregnant women visiting the obstetrics clinic for a routine antenatal check-up was undertaken. Once recruited, all study participants underwent clinical and microbiological investigations for genitourinary infections followed by a dental check-up for the presence of periodontitis. The study participants were followed up until their delivery to record the pregnancy outcomes. Infectious and non-infectious risk factors for PTB and LBW were assessed using univariate and multivariate Cox regression analysis. Independent risk factors for PTB and LBW were reported in terms of adjusted relative risk (ARR) with the 95% confidence interval (CI). Results: Rates of PTB and LBW in the study population were 7.6% and 11.4%, respectively. Previous preterm delivery (ARR, 5.37; 95% CI, 1.5 to 19.1), periodontitis (ARR, 2.39; 95% CI, 1.1 to 4.9), Oligohydramnios (ARR, 5.23; 95% CI, 2.4 to 11.5), presence of Nugent’s intermediate vaginal flora (ARR, 2.75; 95% CI, 1.4 to 5.1), gestational diabetes mellitus (ARR, 2.91; 95% CI, 1.0 to 8.3), and maternal height <1.50 m (ARR, 2.21; 95% CI, 1.1 to 4.1) were risk factors for PTB, while periodontitis (ARR, 3.38; 95% CI, 1.6 to 6.9), gestational hypertension (ARR, 3.70; 95% CI, 1.3 to 10.8), maternal height <1.50 m (ARR, 2.66; 95% CI, 1.3 to 5.1) and genital infection during later stages of pregnancy (ARR, 2.79; 95% CI, 1.2 to 6.1) were independent risk factors for LBW. Conclusions: Our study findings underscore the need to consider screening for potential genitourinary and periodontal infections during routine antenatal care in developing countries.

Item Type: Article
Uncontrolled Keywords: Bacteriuria; bacterial vaginosis; intermediate vaginal flora; low birth weight; periodontitis; premature birth.
Subjects: Medicine > KMC Manipal > Community Medicine
Dentistry > MCODS Manipal > Preventive and Community Dentistry
Medicine > KMC Manipal > Microbiology
Medicine > KMC Manipal > Obstetrics & Gynaecology
Depositing User: KMC Library
Date Deposited: 18 Jun 2016 16:15
Last Modified: 18 Jun 2016 16:15
URI: http://eprints.manipal.edu/id/eprint/146374

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