Estimation of L-Fucose and Sialic Acid as Prognostic Markers in Precancerous Condition in Mangalore Population.

Poojary, Roopesh J and *, Suchetha kumari and *, Nayanatara AK and Shiva, Rashmi Kaup and *, Vinodini N.A and Poojary, Dharnappa (2016) Estimation of L-Fucose and Sialic Acid as Prognostic Markers in Precancerous Condition in Mangalore Population. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7 (3). pp. 2709-2712. ISSN 0975-8585

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Abstract

Oral pre cancer is a lesion found in the oral cavity and oropharynx. Sialic acid (N-acetyl neuraminic acid) and L-fucose (6 deoxy-L galactose) are the monosacharides present in the mammalian cells. Literature review has showed a clear link between these monosaccharides and various carcinomas. Objectives of the present study is to estimate and compare the status of Sialic acid and L-fucose in precancerous patients. Present study is conducted in compliance with the ethical committee guidelines of the institute. Sixty subjects with the age range 20-60 years were included in the current study. The study group included clinically diagnosed cases of oral sub mucous fibrosis, leukoplakia and erythroplakia. These were clinically confirmed cases of oral pre-cancer. L-fucose and sialic acid were measured by Winzlers method in serum sample. The levels of Sialic acid and L-fucose were found to be increased significantly increased in various stages of pre cancer in comparison with the normal subjects (p >0.001).When pre-cancer develops, cell to cell adhesiveness is diminished among these cells and they easily enter into the blood stream. The level of serum Sialic acid and L-Fucose increases along with the severity and inflammation of the tissues.

Item Type: Article
Uncontrolled Keywords: oral pre cancer, sialic acid, L-Fucose, leukoplakia, erythroplakia
Subjects: Dentistry > MCODS Mangalore > Oral Surgery
Medicine > KMC Mangalore > Physiology
Depositing User: KMCMLR User
Date Deposited: 29 Jun 2016 11:07
Last Modified: 29 Jun 2016 11:07
URI: http://eprints.manipal.edu/id/eprint/146429

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