Pyrimidinethione derivatives with tosyl substitution: Synthesis, and antimicrobial property investigation

Shubhalaxmi, . and Manjunatha, B S and Ananda, K and Bhat, Subrahmanya K (2016) Pyrimidinethione derivatives with tosyl substitution: Synthesis, and antimicrobial property investigation. Journal of Applied Pharmaceutical Science, 6 (6). 073-078. ISSN 2231-3354

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Abstract

Substitution of tosyl group on hydroxyacetophenones orhydroxybenzaldehyde and their subsequent condensation yielded several tosyloxy substituted chalcones which were derivatized to obtain the corresponding pyrimidinethione derivatives. The synthesized compounds were characterized by spectroscopic techniques like FT-IR, 1H NMR, 13C NMR, and mass spectrometry. These compounds were subjected to initial screening for their bioactivity using zone of inhibition method and were found moderately active against the tested microorganisms, viz. Mycobacterium smegmatis, Staphylococcus aureus, Escherichia coli, and Candida albicans.

Item Type: Article
Uncontrolled Keywords: Chalcones; Pyrimidine derivatives; Antimicrobial property; Spectral characterization
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 30 Jun 2016 16:09
Last Modified: 30 Jun 2016 16:09
URI: http://eprints.manipal.edu/id/eprint/146448

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